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Subunit vaccine is by physical chemical methods or genetic engineering methods to obtain the main immunogenic proteins of pathogens made of a vaccine which can effectively avoid the use of all pathogens, the biological production of vaccines and lead to security risks, and help to improve the active ingredient in vaccines the concentration, purity, and the development of multivalent, multi-combined vaccine. Has successfully developed sub-unit vaccines, including VPI-mouth disease virus subunit vaccine, Mycobacterium tuberculosis ribosomal subunit vaccine, a variety of bacterial exotoxin subunit vaccine, hepatitis B virus surface antigen subunit vaccine. To date, the development of influenza vaccines for human use has experienced three periods, the first-generation vaccine is an inactivated whole-virus vaccine, the first two semi-cracking generation vaccines, 3rd generation cracking the whole virus, subunit vaccine. Compared with the previous 2-generation vaccines, 3rd-generation vaccines to further remove the virus components have little to do with immune function and stress on the body has the role of macromolecular protein and heat transfer, while the main immunogenic antigen of influenza virus hemagglutinin ( HA) and neurological acid enzyme (NA) concentration, so this vaccine to the body's stress is small, fast rise in antibodies after vaccination to maintain long time, has a good immune effect, but also has a higher bio-security. At present, populations in many countries have begun to use the first three-generation full-lysis of influenza virus subunit vaccine. But for swine flu, this sub-unit vaccine production costs are too expensive in the short term mainstream is unlikely that the immune products. On the contrary, people put more attention to the 4th generation of genetic engineering subunit vaccine.

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