Google

The classic physiological reason that bronchial asthma, bronchial smooth muscle spasm and hypertrophy are the main pathological changes caused by asthma, but in recent years, the study concluded that in terms of pathogenesis, or in the impact of ventilation in the airway, airway inflammation and inflammation -induced airway remodeling may be more important than the smooth muscle spasm. In fact large, medium and bronchial cartilage ring of the ring-supporting force can be greatly limited the effect of airway smooth muscle spasm, but in small bronchi, airway smooth muscle spasm can still be induced by the more obvious bronchial stenosis. Is generally believed that airway inflammation in asthma patients with small airway-based, but Martyn recent studies have shown that airway inflammation in asthma patients can be found in large, small airway bronchial up to 20 multi-level alveolar, suggesting that the airways of asthma Inflammation is a broad and diffuse, and can involving the whole airway, usually the closer the lumen of the organizational level, the inflammatory injury of the more serious, so airway epithelial inflammatory injury is often the most serious.
About the nature of airway inflammation is still some controversy, there are allergic inflammation, neurogenic inflammation, viral and other infectious inflammation of the theory, according to airway inflammation in cell infiltration with eosinophils mainly Most Scholars tend to believe that the airway inflammation of asthma is allergic to. Also believe that allergen-induced immediate-phase asthmatic reactions, causing asthma causes airway obstruction to airflow in the main airway smooth muscle spasm; in allergen-induced late-phase asthmatic reactions, airway mucosa mainly in the main airway allergic inflammatory changes are allergic airway inflammation caused by inflammatory mucosal edema, hyperemia, exudation increase, or even caused the formation of mucus plug the airway obstructive changes in recent years through the right paragraph in the lungs in patients with asthma allergen bronchial provocation test before and after the pathological examination of bronchoscopy biopsy confirmed this.
Airway remodeling in chronic airway inflammation that occurs based on chronic airway inflammation is the inevitable result of development, due to the long-term sustainability of the airway inflammation of repeated attacks, repeated repair, resulting in tissue proliferation and remodeling took place. Airway remodeling occurred mainly in adult asthma patients, the majority of adult patients with chronic asthma can produce different degrees of airway remodeling, asthma in children very rare. Airway epithelial inflammatory injury - repair - re-injury - and then repair the resulting airway remodeling of asthma may develop into an important refractory asthma pathophysiological basis. The mechanism of airway remodeling in the release of inflammatory cells and airway inflammation-promoting factor and growth factor-related gene expression, other cytokines and inflammatory mediators are also involved in the mechanism of airway remodeling. Airway remodeling can be demonstrated in clinical irreversible or poorly reversible airway ventilation dysfunction and airway hyper-responsiveness, while still be able to appear the characteristics of late-phase asthmatic reaction.

http://798dcdrgwxs7hsh5p50nk34a21.hop.clickbank.net/
http://543a851ry3ne559w5dxlce-9nw.hop.clickbank.net/
http://e4196j3jn5ead0e7ndo8nwhq0c.hop.clickbank.net/
http://fdb30j0gpyea9r933jsek8uk5f.hop.clickbank.net/