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It is the virus structure is spherical or filamentous form. Limited experience in clinical isolates of the laboratory process and tissue culture, there are more filamentous than spherical particles, but mainly spherical particles.
In the H1N1 virus genome contains eight monomers (non-matching) RNA chain code for 11 proteins (HA, NA, NP, M1, M2, NS1, NEP, PA, PB1, PB1-F2, PB2). The total genome size is 13588. Divided nature of the genome to allow the entire gene in cells of different viral vectors exist. 8 RNA, in part:
* Under the encoding hemagglutinin of infection to the host organism HA. Influenza viruses bud from the apical surface of polarized epithelial cells (such as bronchial epithelial cells) into the cavity the lungs, it is often Legionella pneumophila. The reason is, HA of tryptase kt limited to the lungs. However, in 2004 the H5 and H7 subtypes of avian influenza virus, the growth of the virus in other organs than the lung infection faster.
* NA neuraminidase.
* NP NP.
* M matrix protein.
* NS two distinct non-structural proteins (NS1 and NEP).
* PA RNA polymerase.
* PB1, and the RNA polymerase PB1 - F2 generation of protein.
* PB2 RNA polymerase.
Nucleoprotein synthesis of RNA occurs in the nucleus, protein synthesis occurs in the cytoplasm. The virus core to leave the nuclear transfer of the cell membrane, plaque virus transmembrane proteins (hemagglutinin, neuraminidase protein and M2), and the supply of a basic layer of M1 protein, and through these complementary complete enveloped virus release into the extracellular fluid.
1998 North Carolina from the United States was isolated H3N2 subtype h1n1, the HA, NA, and PB1 gene of influenza virus genes Wei Ren, M, NP and NS genes of swine influenza virus gene, PB2, PA genes of avian-type influenza virus genes [10]. In 1978, an outbreak of H1N2 in Japan by the H1N1 and H3N2 genetic recombination and the emergence of new subtypes [11]. Domestic pig isolated from Shandong H9N2 influenza viruses, analysis may be caused by chicken and duck influenza viruses result of the reorganization [10]. Following the H9N2 subtype of influenza A virus in 1998 for the first time isolated from pigs, studies show that, by partial sequence analysis showed that the domestic swine H9N2 subtype avian influenza viruses isolated a high degree of homology. SI and human influenza can occur between the cross-infection and spread. In 1978, one of the pigs from Taiwan to the H3N2 subtype was isolated by sequencing found that the virus occurred in a human influenza virus and SI recombinant viral gene fragments [12].
As the H1N1 immune pressure by the larger, eight gene segments of the amino acid changes accumulate, the apparent antigenic variation. In isolated geographical environment, H1N1 has remained relatively sustainable existence and the genetic stability [13-14].
Swine influenza virus as a "mixer" in influenza viruses cross species barriers to infect new host plays an important role. Pig epithelial cells due to sialic acid 2,6 - galactosidase, and sialic acid 2,3 - galactosidase, human influenza virus can be combined with the former, while the avian flu virus combines with the latter, therefore, pig epithelial cells can be human influenza viruses and avian influenza virus infection, but have become among strains of live recombinant vectors [15-16].
As h1n1 can directly infect humans, causing human illness or death, significantly increasing their public health significance. H1N1 to strengthen research in the world economy to reduce losses and improve the health of human health, have far-reaching significance.
Influenza A virus H1N1 subtype (denoted as A (H1N1) or H1N1), also known as the H1N1 virus, which is a kind of influenza virus is also infected with human influenza virus, one of the most common. Some types of H1N1 can be transmitted between humans, including the 1918 influenza pandemic, while others can be transmitted between birds and pigs.
The genetic composition of the virus in dispute. According to its hemagglutinin and neuraminidase protein, the type, the scientists agree that this is an H1N1 virus. It is by people, pigs and avian influenza, the composition of genetic material, while the World Health Organization that it is mainly composed of swine influenza genes.
Novel H1N1 influenza (swine flu) was originally a type of pigs infected with the disease, influenza A viruses belong to. U.S. CDC data show that the United States prior to that it has been the case of human infection with swine influenza. Mexico and the United States is currently an outbreak of swine flu outbreak, that is, caused by H1N1 virus, but such a combination of swine influenza, human influenza, little is known about the epidemiology of new viruses.
March-April 2009, Mexico, the outbreak of H1N1 outbreak, resulting in over one hundred people are infected. Epidemic then spread throughout the world. April 30, 2009 early morning, the World Health Organization global influenza pandemic warning level raised to level 5. http://c707dhwtoxm43vc5fzlo8z3ye6.hop.clickbank.net/
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